ATP T432 Plus
One of the key functions of the thyroid is to drive your metabolism. If your metabolism is slow, fat burning becomes difficult. Sure, you hit the gym, run the kilometres however; if your thyroid is low, you will only be burning fat optimally during these periods of exercise. Even if you exercise for one hour a day, that is still less than 5% of your day you are burning fat effectively. If you had an optimal metabolism and thyroid function, you would be burning fat for 24 hours a day, 7 days per week plus having more energy. Does that sound more appealing?
Symptom picture checklist for slow or under-active thyroid function
- generalised weight gain that is difficult to account for
- fluid retention
- apathy and depression
- too tired and cranky to care or tolerate ‘idiots’ (impatient towards others)
- cold or overly sensitive to cold breeze, drinks and foods
- swollen and bloated
- slow bowels with excessive bloating and gas and fullness
- poor circulation and fluid retention
- dry, weak and poor quality hair
- dry skin
- weak, brittle or poor quality finger and toe nails
- sluggish bowels and constipation
- burping, farting and gurgling guts
WHAT IS T432 PLUS?
T432 Plus is a unique combination of super foods and spices used to maintain healthy metabolism from around the globe; including Ayurvedic, Traditional Chinese Medicine, and South American traditional medicine systems. The active ingredients in these super foods and spices have been isolated and concentrated and using the tools provided by modern science and combined with critical thyroid cofactors Zinc, Selenium and Iodine to ensure efficacy, consistency and reliability.
How does T432 Plus help fat burning?
- Maximise thermogenesis and Basal Metabolic Rate (BMR)
- Correct insulin resistance
- Control appetite and cravings
- Create ideal thermogenic hormonal profile
Thyroid hormone for fat loss
Thyroid hormones control your metabolic rate, digestive function and thermogenic capacity. It is essential to control the thyroid hormone pathways to ensure that it works as a potent thermogenic compound. There are many factors that will alter the thyroid hormone conversion pathways. Here is your strategy to target your thyroid function.
- Support healthy thyroid hormone profile
- Maximise Thyroxine (T4) production and release
- Enhance the conversion of T4 to the more active form Triiodothyronine (T3)
- and then support conversion of T3 through to the potent thermogenic mitochondrial activating T2
- Boost the thermogenic form of thyroid hormone, Diiodothyronine (T2)
- Reduce reverse T3 (rT3) (a potential suppressor of thyroid function)
Figure 1. The conversion of T4 through to T3 and then through to T2
THE THYROID HORMONES
T4 is virtually the building blocks to the ‘active’ thyroid hormones. T4 has only 1/10th the activity of T3. A form of T4 is the synthetic drug (Oroxine) commonly prescribed by medical doctors for people with low thyroids. When an iodine is removed from T4 and converted to T3, the hormone becomes vastly more active.
T3 is the major pace maker of the body binding to nuclear receptors (thyroid hormone receptors). It regulates resting metabolic rate (increases the minimal level of calories that a person needs in order to sustain life while resting), thermogenesis, heart rate, increasing the consumption of both oxygen and energy in the body, the synthesis and degradation of the macromolecules, increase the rate of protein degradation and synthesis and controls the growth of bones.
rT3 (Reverse T3)
T4 can convert down two different pathways; either conversion to T3 or Reverse T3. T3 is 7x more potent thermogenic than T4. Reverse T3 is 1/100th as potent as T4 as a thermogenic and will bind and block the T3 receptors preventing the thermogenic T3 from acting directly and converting to the most potent thermogenic T2.
Until recent years, T2, because of its very low affinity for thyroid hormone receptors, was considered an inactive metabolite of thyroid hormones T4 and T3. Several observations, however, led to a reconsideration of this idea. T2 rapidly stimulates cellular mitochondrial respiration regulating thermogenesis and energy expenditure whilst those of T3 are initiated via the nucleus and involve genes and protein synthesis. T2 has a more rapid effect on mitochondrial respiration than T3 and the effects of T2 being evident as soon as 1 h after its injection, while that of T3 became evident only after 24h. T2 rapidly increases the activity of carnitine dependant enzymes, which are the rate limiting step for fat burning. This increases the ability of the mitochondria to import and oxidize fatty acids. T2 has the ability to reduce adiposity and dyslipidaemia and to prevent the development of liver steatosis (fatty liver) showing a rapid T2-induced increase in the ability of mitochondria to import and oxidize fatty acids.
Figure 2. This graph shows T2 is as potent as T3 but exerts its effects more rapidly.
What causes reduced thyroid hormone activity?
- Estrogen dominance
- Stress and cortisol
- Inflammation and cytokines (chemicals released from immune cells during infection, allergy, toxic exposure and stress)
- Obesity and adipokines (chemicals released from fat cells that have immune, inflammatory and hormonal effects)
- Nutritional deficiencies – Iodine, Zinc and selenium
- Foods – Soy, Gluten, green tea catechins EGCG
Thyroid raw material nutrient base
- Tyrosine – Provides the back bone structure for T4, T3 and T2
- Iodine – Required for the production of thyroid hormones (T4, T3 and T2)
- Chromium – Helps make insulin work better thus reducing insulin resistance
- Zinc – Required for the conversion of T4 to T3
- Selenium – Required for the conversion of T4 to T3
Yerba Mate (ilex paraguariensis)
- Contains Caffeine
- Contains GLP-1 – reduces appetite, cravings for foods, alcohol and other recreational drugs
- Increases energy, focus, memory and mental clarity
- Increases energy expenditure due to the stimulation of a higher basal metabolic rate
- Increase thermogenesis
- Stimulate catacholamines to improve energy, arousal and lipolysis
- Phosphodiesterase Inhibitor (PDE) inhibitor to preserve cAMP
- Inhibits adipogenesis (creation of new fat cells)
- Improve insulin sensitivity and reduces insulin resistance
- Improves leptin sensitivity and reduces leptin resistance
Du Zhong (Eucommia ulmoides oliver leaf)
- Phytoandrogen enhances testosterone effects and reduces estrogen dominance
- Increase endurance and exercise performance
- Increases use of ketones and glucose by skeletal muscle
- Improves insulin sensitivity
- Inhibits PDE to increase cAMP
- Modulates adipokines (chemicals released from fat cells that cause obesity, insulin resistance and hormonal imbalances)
- Increases fat burning and thermogenesis
- Suppresses appetite
Cinnamon Bark (Cinnamomum zeylanicum)
- Improves insulin sensitivity and reduces insulin resistance
- Enhance metabolism and thermogenesis
- Protects liver
Coleus Forskohlii (yielding 10mg Forskolin)
- Direct activation of adenylate cyclase to raise cyclic AMP levels
- Increase cAMP
- Increase lipolysis and thermogenesis
- Increase thyroid activity
- Enhance conversion of T4 to T3 and T2
- Reduces estrogen dominance by enhancing progesterone and thyroid hormone activity
Black pepper (Piper nigrum)
- Inhibits adipogenesis (the creation of new fat cells)
- Enhances insulin sensitivity
- Enhances testosterone51
- Inhibits 5 alpha reductase to reduce DHT production
- Enhances thermogenic thyroid hormone profile
- Inhibits adipogenesis
- Inhibits uptake of blood glucose by fat cells
- Enhances uptake of blood glucose by muscle
- Slows down first pass metabolism to enhance the effects of the other ingredients, especially the yerba mate caffeine and GLP-1.
- Naringin can have an antidepressant-like effect as it can increase hippocampal serotonin, norepinephrine and improve cortisol sensitivity, reducing serum cortisol levels.
- enhance fat burning via activation of PPARα transcription factor and up regulation of its fatty acid oxidation target genes
- Naringin is a phosphodiesterase inhibitor preserves the lipolysis stimulating cAMP
- Prevents sterol regulatory element-binding protein 1c-mediated lipogenesis in both liver and muscle by reducing fasting hyperinsulinemia;
- decreases hepatic cholesterol and cholesterol ester synthesis;
- Reduces both VLDL-derived and endogenously synthesized fatty acids, preventing muscle triglyceride accumulation; and
- Improves overall insulin sensitivity and glucose tolerance.
Bladderwrack (Fucus vesiculosus)
- Exerts anti-estrogenic effects
- Aromatase inhibitor
- Inhibits the binding of estradiol to estrogen receptors
- Antioxidant, anti-allergic and anti-inflammatory
- good source of iodine
- Iodine is essential for healthy metabolic rate
- Iodine deficiency is a major cause of obesity and hypothyroidism
- Iodine deficiency causes estrogen dominance
- Bladderwrack is a potent source of iodine and other compounds including fucoidan and fucophlorethols, which have demonstrated powerful anti-estrogen properties.
- Bladderwrack extract inhibits the binding of estradiol to estrogen receptor alpha and beta.
- Phloroglucinol derivatives, belonging to the class of fucophlorethols, isolated from bladderwrack have been shown to be potent aromatase inhibitors.